This stunning property offers a unique blend of residential comfort and high-visibility commercial potential on Portsmouth Avenue in Stratham. The main house is a spacious 4-bedroom, 3.5-bathroom colonial with impressive architectural details, including a grand two-story open railed walkway accessing all bedrooms. The lower level boasts ample parking (for two vehicles in tandem, designed for an RV) with a 12' ceiling, a large finished "man cave," full bath, office, utility room, and storage, all with walk-out access. The first floor features an open kitchen/family room layout, formal dining room, parlor, laundry room, and half bath. A substantial 30' x 30' two-car garage with a built-in second floor was added in 2002. In addition to the main house, a detached 1098 sq ft building, previously used as a salon and antique shop, currently operates as a residential rental. This versatile structure, situated closer to the high-traffic road, offers significant commercial possibilities, or it can continue to generate rental income. It features separate utilities and ample paved parking for 5-7 cars. There are 2 bedrooms, living room, kitchenette, laundry room and an area that was used as a reception space. Many commercial uses are permitted within the Route 33 Legacy Highway Heritage District zoning. This property presents a rare opportunity to live and work in a prime location, combining residential luxury with substantial commercial potential.